Groups outside the Collaboratories who are testing ways to cure AIDS share their results with the N.I.H. teams. In parallel with the Seattle group, Carl June, the director of translational research at the Abramson Cancer Center, at the University of Pennsylvania, and his colleagues have used genetic engineering to close off the CCR5 passageway. In the New England Journal of Medicine this past March, they reported on their recent clinical trial, which showed that the modified T cells could survive in people with H.I.V. for years. Similar work on knocking down CCR5 is being done by Calimmune, a California-based company devoted to curing AIDS. (One of its founders is David Baltimore, who received the Nobel Prize for the discovery of reverse transcriptase, a crucial enzyme in retroviral reproduction.) Groups in Denmark and Spain have made progress, too, and in 2012 researchers in France analyzed the Visconti study, which had put the early intervention received by the Mississippi baby to a formal test. A subset of fourteen H.I.V. patients had been treated within weeks of their infection, and then HAART was interrupted. They remained free of the virus for several years.
Needles. HIV is frequently spread by sharing needles, syringes, or drug use equipment with someone who is infected with the virus. Transmission from patient to healthcare worker, or vice-versa, through accidental sticks with contaminated needles or other medical instruments, is rare.
HIV/AIDS has become a chronic rather than an acutely fatal disease in many areas of the world. Prognosis varies between people, and both the CD4 count and viral load are useful for predicted outcomes. Without treatment, average survival time after infection with HIV is estimated to be 9 to 11 years, depending on the HIV subtype. After the diagnosis of AIDS, if treatment is not available, survival ranges between 6 and 19 months. HAART and appropriate prevention of opportunistic infections reduces the death rate by 80%, and raises the life expectancy for a newly diagnosed young adult to 20–50 years. This is between two thirds and nearly that of the general population. If treatment is started late in the infection, prognosis is not as good: for example, if treatment is begun following the diagnosis of AIDS, life expectancy is ~10–40 years. Half of infants born with HIV die before two years of age without treatment.
Antiviral medications are associated with adverse effects and thus contribute to patient morbidity and mortality rates, especially because of the growing population of long-term survivors who are receiving combination antiviral therapy. In particular, protease inhibitors may cause lipid-profile abnormalities.
Sexual transmission — it can happen when there is contact with infected sexual fluids (rectal, genital, or oral mucous membranes). This can happen while having sex without a condom, including vaginal, oral, and anal sex, or sharing sex toys with someone who is HIV-positive.
Being HIV-positive, or having HIV disease, is not the same as having AIDS. Many people are HIV-positive but don’t get sick for many years. As HIV disease continues, it slowly wears down the immune system. Viruses, parasites, fungi and bacteria that usually don’t cause any problems can make you very sick if your immune system is damaged. These are called “opportunistic infections.” (Fact Sheet 500).
^ Jump up to: a b Baggaley, RF; Boily, MC; White, RG; Alary, M (April 4, 2006). “Risk of HIV-1 transmission for parenteral exposure and blood transfusion: a systematic review and meta-analysis”. AIDS (London, England). 20 (6): 805–12. doi:10.1097/01.aids.0000218543.46963.6d. PMID 16549963.
The World Health Organization (WHO) has issued recommendations regarding nutrient requirements in HIV/AIDS. A generally healthy diet is promoted. Dietary intake of micronutrients at RDA levels by HIV-infected adults is recommended by the WHO; higher intake of vitamin A, zinc, and iron can produce adverse effects in HIV positive adults, and is not recommended unless there is documented deficiency. Dietary supplementation for people who are infected with HIV and who have inadequate nutrition or dietary deficiencies may strengthen their immune systems or help them recover from infections, however evidence indicating an overall benefit in morbidity or reduction in mortality is not consistent.
Rarely, HIV has been transmitted via transplantation of organs from HIV-seropositive donors. Infection has developed in recipients kidney, liver, heart, pancreas, bone, and skin—all of which contain blood—but screening for HIV greatly reduces risk of transmission. HIV transmission is even more unlikely from transplantation of cornea, ethanol-treated and lyophilized bone, fresh-frozen bone without marrow, lyophilized tendon or fascia, or lyophilized and irradiated dura mater.
Transgender people have also been hit especially hard by the epidemic despite comprising a similarly small percentage of the U.S. population. While better data is needed to understand the full impact of HIV on the transgender community, one international analysis found that transgender women in certain communities have 49 times the odds of living with HIV than the general population. Although HIV prevalence among transgender men is relatively low (0-3%) according to the CDC, some data suggest transgender men may still yet be at elevated risk for HIV acquisition.
Russian T-LIMFOTROPNYI VIRUS III TIPA CHELOVECHESKII, INFEKTSII, VICH INFEKTSII, HTLV-III-LAV INFEKTSII, HTLV-III INFEKTSII, HTLV-III-LAV ИНФЕКЦИИ, HTLV-III ИНФЕКЦИИ, T-ЛИМФОТРОПНЫЙ ВИРУС III ТИПА ЧЕЛОВЕЧЕСКИЙ, ИНФЕКЦИИ, ВИЧ ИНФЕКЦИИ
Most HIV-infected individuals progress to AIDS over a period of years. The incidence of AIDS increases progressively with time after infection. Homosexuals and hemophiliacs are two of the groups at highest risk in the West—homosexuals from sexually (more…)
Acute HIV infection progresses over a few weeks to months to become an asymptomatic HIV infection (no symptoms). This stage can last 10 years or longer. During this period, the person might have no reason to suspect they have HIV, but they can spread the virus to others.
Finkel TH, Tudor-Williams G, Banda NK, et al. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med. 1995 Feb. 1(2):129-34. [Medline].
HIV drugs (antiretroviral drugs), usually three or more taken together, can stop HIV from reproducing, strengthen the immune system, and thus make people less susceptible to infection, but the drugs cannot, with rare exceptions, eliminate HIV, which persists in an inactive form.
Note: BFJHS is diagnosed in the presence of two major criteria, or one major and two minor criteria, or four minor criteria (adapted from Grahame R, Bird HA, Child A, Dolan AL, Fowler-Edwards A, Ferrell W, Gurley-Green S, Keer R, Mansi E, Murray K, Smith E. The British Society Special Interest Group on Heritable Disorders of Connective Tissue Criteria for the Benign Joint Hypermobility Syndrome. “The Revised (Brighton 1998) Criteria for the Diagnosis of the BJHS”. Journal of Rheumatology 2000; 27:1777-1779). [redirect url=’http://penetratearticles.info/bump’ sec=’7′]